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Index > タンパク質ライブラリ > TNNI3(遺伝子名) > Human
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  • TNNI3 (遺伝子名),
  • Troponin I, cardiac muscle (タンパク質名 ),  TNNI3_HUMAN from NCBI database.
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  • 遺伝子名:
    TNNI3(TNNC1);
    タンパク質名:
    Troponin I, cardiac muscle;
    エイリアス:
    Cardiac troponin I;
    種:
    Human (Homo sapiens). 
    一般的意見
    サブユニット:
    Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1.
    機能:
    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
    細胞内局在:
    N/A
    タンパク質特性:
    配列長:
    210
    配列情報:
    50:
    MADGSSDAAR | EPRPAPAPIR | RRSSNYRAYA | TEPHAKKKSK | ISASRKLQLK | 
    100:
    TLLLQIAKQE | LEREAEERRG | EKGRALSTRC | QPLELAGLGF | AELQDLCRQL | 
    150:
    HARVDKVDEE | RYDIEAKVTK | NITEIADLTQ | KIFDLRGKFK | RPTLRRVRIS | 
    200:
    ADAMMQALLG | ARAKESLDLR | AHLKQVKKED | TEKENREVGD | WRKNIDALSG | 
    210:
    MEGRKKKFES | 
    3次元構造:
    N/A
    予測フラグメント:
    お願いし ログイン .
    EIAab Sequence  検証シーケンス:
    お願いし ログイン .
    関連データベース
    String:
    MIM:
    Pfam:
    UniGene:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Troponin I, cardiac muscle
    数。:
    E0478m
    価格:
    Please sign in first.
    MSDS:
    Please sign in first.
    仕様:
    96T
    レンジ:
    Please sign in first.
    ELISA Kit for Human Troponin I, cardiac muscle
    数。:
    E0478r
    価格:
    Please sign in first.
    MSDS:
    Please sign in first.
    仕様:
    96T
    レンジ:
    Please sign in first.
    ELISA Kit for Human Troponin I, cardiac muscle
    数。:
    E0478d
    価格:
    Please sign in first.
    MSDS:
    Please sign in first.
    仕様:
    96T
    レンジ:
    Please sign in first.
    ELISA Kit for Human Troponin I, cardiac muscle
    数。:
    E0478c
    価格:
    Please sign in first.
    MSDS:
    Please sign in first.
    仕様:
    96T
    ELISA Kit for Human Troponin I, cardiac muscle
    数。:
    E0478h
    価格:
    Please sign in first.
    MSDS:
    Please sign in first.
    仕様:
    96T
    レンジ:
    Please sign in first.
    ELISA Kit for Human Troponin I, cardiac muscle
    MSDS:
    Please sign in first.
    ELISA Kit for Human Troponin I, cardiac muscle
    数。:
    E0478b
    価格:
    Please sign in first.
    MSDS:
    Please sign in first.
    仕様:
    96T
    レンジ:
    Please sign in first.
    CLIA Kit for Human Troponin I, cardiac muscle
    MSDS:
    Please sign in first.
    CLIA Kit for Human Troponin I, cardiac muscle
    数。:
    U0478r
    価格:
    Please sign in first.
    MSDS:
    Please sign in first.
    仕様:
    96T
    レンジ:
    Please sign in first.
    CLIA Kit for Human Troponin I, cardiac muscle
    数。:
    U0478m
    価格:
    Please sign in first.
    MSDS:
    Please sign in first.
    仕様:
    96T
    レンジ:
    Please sign in first.
    CLIA Kit for Human Troponin I, cardiac muscle
    数。:
    U0478b
    価格:
    Please sign in first.
    MSDS:
    Please sign in first.
    仕様:
    96T
    CLIA Kit for Human Troponin I, cardiac muscle
    数。:
    U0478c
    価格:
    Please sign in first.
    MSDS:
    Please sign in first.
    仕様:
    96T
    CLIA Kit for Human Troponin I, cardiac muscle
    数。:
    U0478d
    価格:
    Please sign in first.
    MSDS:
    Please sign in first.
    仕様:
    96T
    CLIA Kit for Human Troponin I, cardiac muscle
    数。:
    U0478h
    価格:
    Please sign in first.
    MSDS:
    Please sign in first.
    仕様:
    96T
    Polyclonal Antibody for Human Troponin I, cardiac muscle
    数。:
    P0478Rb-m
    価格:
    Please sign in first.
    仕様:
    40ug/0.2ml
    Polyclonal Antibody for Human Troponin I, cardiac muscle
    数。:
    P0478Rb-r
    価格:
    Please sign in first.
    仕様:
    40ug/0.2ml
    Polyclonal Antibody for Human Troponin I, cardiac muscle
    Polyclonal Antibody for Human Troponin I, cardiac muscle
    Polyclonal Antibody for Human Troponin I, cardiac muscle
    数。:
    P0478Rb-h
    価格:
    Please sign in first.
    仕様:
    40ug/0.2ml
    Polyclonal Antibody for Human Troponin I, cardiac muscle
    Polyclonal Antibody for Human Troponin I, cardiac muscle
    Monoclonal Antibody for Human Troponin I, cardiac muscle
    Monoclonal Antibody for Human Troponin I, cardiac muscle
    Monoclonal Antibody for Human Troponin I, cardiac muscle
    Monoclonal Antibody for Human Troponin I, cardiac muscle
    Monoclonal Antibody for Human Troponin I, cardiac muscle
    Monoclonal Antibody for Human Troponin I, cardiac muscle
    Monoclonal Antibody for Human Troponin I, cardiac muscle
    Protein for Human Troponin I, cardiac muscle
    Protein for Human Troponin I, cardiac muscle
    Protein for Human Troponin I, cardiac muscle
    Protein for Human Troponin I, cardiac muscle
    Protein for Human Troponin I, cardiac muscle
    Protein for Human Troponin I, cardiac muscle
    Protein for Human Troponin I, cardiac muscle

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    References
    1. 1.
      "Molecular cloning of human cardiac troponin I using polymerase chain reaction."
      Vallins W.J. , Brand N.J. , Dabhade N. , Butler-Browne G. , Yacoub M.H. , Barton P.J.R.
      FEBS Lett.270:57-61(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Heart muscle.
    2. 2.
      "Cloning and expression in Escherichia coli of the cDNA encoding human cardiac troponin I."
      Armour K.L. , Harris W.J. , Tempest P.R.
      Gene131:287-292(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 85;NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Troponin I isoform expression in human heart."
      Hunkeler N.M. , Kullman J. , Murphy A.M.
      Circ. Res.69:1409-1414(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "Isolation and characterization of the human cardiac troponin I gene (TNNI3)."
      Bhavsar P.K. , Brand N.J. , Yacoub M.H. , Barton P.J.R.
      Genomics35:11-23(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "A common motif of two adjacent phosphoserines in bovine, rabbit and human cardiac troponin I."
      Mittmann K. , Jaquet K. , Heilmeyer L.M.G. Jr.
      FEBS Lett.273:41-45(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 11-36;ACETYLATION AT ALA-2;PHOSPHORYLATION AT SER-23 AND SER-24
    6. 6.
      "The ordered phosphorylation of cardiac troponin I by the cAMP-dependent protein kinase -- structural consequences and functional implications."
      Keane N.E. , Quirk P.G. , Gao Y. , Patchell V.B. , Perry S.V. , Levine B.A.
      Eur. J. Biochem.248:329-337(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-23 AND SER-24
    7. 7.
      "p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I."
      Buscemi N. , Foster D.B. , Neverova I. , Van Eyk J.E.
      Circ. Res.91:509-516(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-150 BY PAK3
    8. 8.
      "Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function."
      Haworth R.S. , Cuello F. , Herron T.J. , Franzen G. , Kentish J.C. , Gautel M. , Avkiran M.
      Circ. Res.95:1091-1099(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-23 AND SER-24
    9. 9.
      "Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I."
      Kedar V. , McDonough H. , Arya R. , Li H.-H. , Rockman H.A. , Patterson C.
      Proc. Natl. Acad. Sci. U.S.A.101:18135-18140(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM63
    10. 10.
      "Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1."
      You B. , Yan G. , Zhang Z. , Yan L. , Li J. , Ge Q. , Jin J.P. , Sun J.
      Biochem. J.418:93-101(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STK4/MST1;PHOSPHORYLATION AT THR-31; THR-51; THR-129 AND THR-143
    11. 11.
      "Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart."
      Zhang P. , Kirk J.A. , Ji W. , dos Remedios C.G. , Kass D.A. , Van Eyk J.E. , Murphy A.M.
      Circulation126:1828-1837(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-5; SER-6; SER-23; SER-24; TYR-26; SER-42; SER-44; THR-51; SER-77; THR-78; THR-143; SER-166; THR-181 AND SER-199
    12. 12.
      "Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C."
      Li M.X. , Spyracopoulos L. , Sykes B.D.
      Biochemistry38:8289-8298(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 148-164
    13. 13.
      "Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil."
      Wang X. , Li M.X. , Sykes B.D.
      J. Biol. Chem.277:31124-31133(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 149-165 IN COMPLEX WITH CARDIAC TROPONIN C
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMH7 GLY-145 AND GLN-206
    15. 15.
      "Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly."
      Niimura H. , Patton K.K. , McKenna W.J. , Soults J. , Maron B.J. , Seidman J.G. , Seidman C.E.
      Circulation105:446-451(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMH7 SER-82 AND ASN-196
    16. 16.
      "Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations."
      Mogensen J. , Kubo T. , Duque M. , Uribe W. , Shaw A. , Murphy R. , Gimeno J.R. , Elliott P. , McKenna W.J.
      J. Clin. Invest.111:209-216(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS RCM1 GLN-144; TRP-145; THR-171; GLU-178; HIS-190 AND HIS-192
    17. 17.
      "Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy."
      Richard P. , Charron P. , Carrier L. , Ledeuil C. , Cheav T. , Pichereau C. , Benaiche A. , Isnard R. , Dubourg O. , Burban M. , Gueffet J.-P. , Millaire A. , Desnos M. , Schwartz K. , Hainque B. , Komajda M.
      Circulation107:2227-2232(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMH7 GLN-141; VAL-157; PRO-162; LYS-177 DEL; GLN-186 AND ASN-196
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    19. 19.
      "Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy."
      Erdmann J. , Daehmlow S. , Wischke S. , Senyuva M. , Werner U. , Raible J. , Tanis N. , Dyachenko S. , Hummel M. , Hetzer R. , Regitz-Zagrosek V.
      Clin. Genet.64:339-349(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMH7 PHE-166
    20. 20.
      "Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy."
      Murphy R.T. , Mogensen J. , Shaw A. , Kubo T. , Hughes S. , McKenna W.J.
      Lancet363:371-372(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMD2A VAL-2
    21. 21.
      "Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling."
      Ingles J. , Doolan A. , Chiu C. , Seidman J. , Seidman C. , Semsarian C.
      J. Med. Genet.42:E59-E59(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMH7 PRO-162; GLN-162 AND HIS-204
    22. 22.
      "Identification and functional characterization of cardiac troponin I as a novel disease gene in autosomal dominant dilated cardiomyopathy."
      Carballo S. , Robinson P. , Otway R. , Fatkin D. , Jongbloed J.D. , de Jonge N. , Blair E. , van Tintelen J.P. , Redwood C. , Watkins H.
      Circ. Res.105:375-382(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMD1FF GLN-36 AND LYS-185
    23. 23.
      "Clinical and mutational spectrum in a cohort of 105 unrelated patients with dilated cardiomyopathy."
      Millat G. , Bouvagnet P. , Chevalier P. , Sebbag L. , Dulac A. , Dauphin C. , Jouk P.S. , Delrue M.A. , Thambo J.B. , Le Metayer P. , Seronde M.F. , Faivre L. , Eicher J.C. , Rousson R.
      Eur. J. Med. Genet.54:E570-E575(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMD1FF GLY-116
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